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DeCS
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Descriptor Inglés:
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SAM Domain and HD Domain-Containing Protein 1
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Descriptor Español:
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proteína 1 que contiene dominios SAM y HD
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Descriptor Portugués:
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Proteína 1 com Domínio SAM e Domínio HD
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Sinónimos Inglés:
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SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase
SAMHD1 Protein
SAMHD1 dNTPase
SAM Domain and HD Domain Containing Protein 1
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Categoría:
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D08.811.277.040.725
D08.811.277.352.700.843
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Definición Inglés:
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A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2). |
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Nota Histórica Inglés:
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2018
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Calificadores Permitidos Inglés:
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Número del Registro:
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57002
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Identificador Único:
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D000076106
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Ocurrencia en la BVS:
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Similar:
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DeCS CID-10 LILACS
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