Expresión de búsqueda:
PYRIN
Descriptores Encontrados:
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DeCS
Descriptor
Inglés
:
Pyrin
Descriptor
Español
:
pirina
Descriptor
Portugués
:
Pirina
Sinónimos
Inglés
:
MEFV Protein
Marenostrin
Mediterranean Fever Protein
TRIM20 Protein
Categoría:
D12.776.220.909
D12.776.934.750
Definición
Inglés
:
A tripartite motif protein that consists of an N-terminal
pyrin domain
, a central coiled-coil region and B-box type ZINC
FINGER
, and C-terminal regions that mediate homotrimerization and interactions with other
proteins
(the B30.2/SPRY DOMAIN). It is expressed primarily by mature
GRANULOCYTES
and associates with the
cytoskeleton
in the perinuclear area as well as
AUTOPHAGOSOMES
, where it co-ordinates the assembly of
AUTOPHAGY-RELATED PROTEINS
and degradation of INFLAMMASOME components. It functions in INNATE
IMMUNITY
and
INFLAMMATION
;
mutations
in the Pyrin protein (MEFV) gene are associated with
FAMILIAL MEDITERRANEAN FEVER.
Relacionados
Inglés
:
Pyrin Domain
Nota Histórica
Inglés
:
2017 (1997)
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
56595
Identificador Único:
D000071198
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
LILACS