Expresión de búsqueda:
ATAXINS
Descriptores Encontrados:
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DeCS
Descriptor
Inglés
:
Ataxins
Descriptor
Español
:
ataxinas
Descriptor
Portugués
:
Ataxinas
Sinónimos
Inglés
:
Ataxin Proteins
Spinocerebellar Ataxia Proteins
Ataxia Proteins, Spinocerebellar
Proteins, Ataxin
Proteins, Spinocerebellar Ataxia
Categoría:
D12.776.631.069
D12.776.660.075
Definición
Inglés
:
A
family
of predominantly
nuclear proteins
that regulate gene transcription and protein degradation. The expansion of CAG
trinucleotide repeats
in genes that encode
Ataxins
is associated with
SPINOCEREBELLAR ATAXIAS
(SCA). In SCA
patients
, the number of CAG repeats correlates with the severity of
disease
and inversely correlates with the age of
disease
onset.
Relacionados
Inglés
:
Spinocerebellar Ataxias
Nota Histórica
Inglés
:
2016
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
56001
Identificador Único:
D000067528
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
LILACS